Choi, Eun Ju Kwon, Hak Cheol Sohn, Young Chang Nam, Chun Woo Park, Hyun Bong Kim, Cheol Young Yang, Hyun Ok 2024-01-20T21:30:35Z 2024-01-20T21:30:35Z 2021-09-03 2009-06 0253-6269 https://pubs.kist.re.kr/handle/201004/132459 A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 mu g/mL and 50 mu g/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent 'hangovers' after alcohol intake. English PHARMACEUTICAL SOC KOREA LUPIN ALKALOIDS ROOTS DEHYDROGENASE FLAVANONES FLOWERS NAKAI Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes Article 10.1007/s12272-009-1606-2 1 ARCHIVES OF PHARMACAL RESEARCH, v.32, no.6, pp.851 - 855 ARCHIVES OF PHARMACAL RESEARCH 32 6 851 855 scie scopus kci ART001348846 000267390300007 2-s2.0-68149125480 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article LUPIN ALKALOIDS ROOTS DEHYDROGENASE FLAVANONES FLOWERS NAKAI Echinosophora koreensis Flavonoids 3-Hydroxy-kenusanone B Alcohol dehydrogenase (ADH) Aldehyde dehydrogenase (ALDH)