Kim, So-Young Park, Hyeong Beom Cho, Jung-Hyuck Yoo, Kyung Ho Oh, Chang-Hyun 2024-01-20T21:31:29Z 2024-01-20T21:31:29Z 2021-09-03 2009-05-01 0960-894X https://pubs.kist.re.kr/handle/201004/132496 The synthesis of a new series of oxazolidinones having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound Ih having fluoro group showed the most potent antibacterial activity. (C) 2009 Published by Elsevier Ltd. English Pergamon Press Ltd. CONFORMATIONALLY CONSTRAINED ANALOGS IN-VITRO ACTIVITY TRICYCLIC OXAZOLIDINONES RESISTANCE QUINOLONE SAR Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties Article 10.1016/j.bmcl.2009.03.025 1 Bioorganic & Medicinal Chemistry Letters, v.19, no.9, pp.2558 - 2561 Bioorganic & Medicinal Chemistry Letters 19 9 2558 2561 scie scopus 000265137100040 2-s2.0-64249111052 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CONFORMATIONALLY CONSTRAINED ANALOGS IN-VITRO ACTIVITY TRICYCLIC OXAZOLIDINONES RESISTANCE QUINOLONE SAR Oxazolidinones Antibacterial activity Spiro[2,4]heptane