Lee, Sang Kyu Kim, Yoon Suh, SungIll Suh, Yong Jun In, Moon Kyo Kim, Dong-Hyun Jin, Changbae Yoo, Hye Hyun 2024-01-20T21:33:14Z 2024-01-20T21:33:14Z 2021-09-03 2009-04-15 0379-0738 https://pubs.kist.re.kr/handle/201004/132566 Recently, 'detox' agents have been popularly used as forms of diets or nutritional supplements. Especially, several cases have been reported that these detox agents have been used to mask drug tests among drug abusers. In the present study, capsule and drink types of detox agents were evaluated for their ability to alter the elimination of methamphetamine (MA) in rats. For this study, MA and its major metabolite, amphetamine (AP) in urine samples were determined using LC-tandem mass spectrometry after administration of the detox agents to MA-treated rats. As a result, significant differences were not shown between control and detox-dosed groups in the amounts of MA and AP excreted into urine as well as the volume of excreted urine. This result suggests that the detox agents tested may not affect the metabolism or elimination of MA and further might have minimal effect on narcotics detection in the urine samples of drug abusers. (C) 2009 Elsevier Ireland Ltd. All rights reserved. English ELSEVIER IRELAND LTD Detox agents do not affect the pharmacokinetics of methamphetamine in the rat Article 10.1016/j.forsciint.2009.01.007 1 FORENSIC SCIENCE INTERNATIONAL, v.186, no.1-3, pp.E21 - E24 FORENSIC SCIENCE INTERNATIONAL 186 1-3 E21 E24 scie scopus 000207819300006 2-s2.0-62749107543 Medicine, Legal Legal Medicine Article Detox agents Methamphetamine Amphetamine Elimination Drug test