Chae, Choong-Sik Park, Jin-Soo Chung, Soon-Chun Kim, Tae-Im Lee, So-Hyoung Yoon, Kyung-Mi Shin, Jongheon Oh, Ki-Bong 2024-01-20T21:35:20Z 2024-01-20T21:35:20Z 2021-09-03 2009-03-15 0960-894X https://pubs.kist.re.kr/handle/201004/132651 Two ink genes, inkO and inkD, responsible for the earliest steps of K252a biosynthetic pathway, from Nonomurea longicantena JCM 11136 were heterologously coexpressed in Streptomyces albus J1074. The resultant strain accumulated compound that was purified by HPLC and studied by NMR. Coexpression of inkOD yielded chromopyrrolic acid, the key intermediate in an indolocarbazole biosynthesis. (C) 2009 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. BIOSYNTHETIC GENE-CLUSTER LECHEVALIERIA-AEROCOLONIGENES ATCC-39243 INDOLOCARBAZOLE COMPOUNDS ANTICANCER AGENTS REBECCAMYCIN GENERATION DERIVATIVES Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus Article 10.1016/j.bmcl.2009.02.026 1 Bioorganic & Medicinal Chemistry Letters, v.19, no.6, pp.1581 - 1583 Bioorganic & Medicinal Chemistry Letters 19 6 1581 1583 scie scopus 000263933800006 2-s2.0-61349158124 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article BIOSYNTHETIC GENE-CLUSTER LECHEVALIERIA-AEROCOLONIGENES ATCC-39243 INDOLOCARBAZOLE COMPOUNDS ANTICANCER AGENTS REBECCAMYCIN GENERATION DERIVATIVES K252a Heterologous expression Chromopyrrolic acid Streptomyces albus J1074