Ahn, Chan Mug Park, Byong-Gon Woo, Ho Bum Ham, Jungyeob Shin, Woon-Seob Lee, Seokjoon 2024-01-20T21:35:33Z 2024-01-20T21:35:33Z 2021-09-03 2009-03-01 0960-894X https://pubs.kist.re.kr/handle/201004/132659 In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. ENDOTHELIN-1-INDUCED CONTRACTION MULTIDRUG-RESISTANCE RAT AORTA EFFICACY REVERSAL SAFETY Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits Article 10.1016/j.bmcl.2009.01.019 1 Bioorganic & Medicinal Chemistry Letters, v.19, no.5, pp.1481 - 1483 Bioorganic & Medicinal Chemistry Letters 19 5 1481 1483 scie scopus 000263891200046 2-s2.0-60449116666 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ENDOTHELIN-1-INDUCED CONTRACTION MULTIDRUG-RESISTANCE RAT AORTA EFFICACY REVERSAL SAFETY Organic synthesis Curcumin Sulfonyl curcumin mimics Vasodilatation Basilar artery