정세진 Ibrahim Mustafa El-Deeb So-Ha Lee 2024-01-20T21:35:52Z 2024-01-20T21:35:52Z 2021-09-06 2009-03 1225-9098 https://pubs.kist.re.kr/handle/201004/132673 This study is focused on the synthesis of urea and amide derivatives particularly, since the amide moiety is an essential binding group at the binding site. Urea derivatives 3-7 and 13-14 were obtained by reaction of 2-aminopyrimidines and other amines with diverse isocyanates in pyridine as a solvent under reflux. The urea derivatives were obtained in low yield because of the highly electron deficient nature of the amino group of the 2-aminopyrimidine. Amide derivatives 8-10 were obtained in moderate yields by reaction of compound 1 with aryl chloride derivatives. Also, Arylamine 11 was synthesized by Buchwald-Hartwig amination in moderate yields. Most of the compound did not show good activity against A374P melanoma cells, compared with Sorafenib as control compound. English 한국응용과학기술학회 Synthesis of a New 4-(Pyridin-3-yl)pyrimidine Derivatives for Anticancer Activity Article 2 한국응용과학기술학회지, v.26, no.1, pp.29 - 37 한국응용과학기술학회지 26 1 29 37 kci ART001327944 Anticancer activity 4-(pyridin-3-yl)pyrimidine derivatives A375P melanoma celsl B-Raf