Kim, Mi Kyoung Park, Kwang-su Yeo, Woon-Seok Choo, Hyunah Chong, Youhoon 2024-01-20T22:01:37Z 2024-01-20T22:01:37Z 2021-09-03 2009-02-01 0968-0896 https://pubs.kist.re.kr/handle/201004/132751 In order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and cell permeability. Among the synthesized quercetin prodrugs, quercetin-glutamic acid conjugate Qu-E (4g/5g) showed remarkable increases in water solubility, stability, and cell permeability compared with quercetin, which warrants further development as a quercetin prodrug. (c) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD TANDEM MASS-SPECTROMETRY INTESTINAL OLIGOPEPTIDE TRANSPORTER LIQUID-CHROMATOGRAPHY MODEL PRODRUGS TRANSEPITHELIAL TRANSPORT FLAVONOL METABOLITES DIETARY FLAVONOIDS BETA-GLUCURONIDASE HUMAN PLASMA IDENTIFICATION In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates Article 10.1016/j.bmc.2008.12.043 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.17, no.3, pp.1164 - 1171 BIOORGANIC & MEDICINAL CHEMISTRY 17 3 1164 1171 scie scopus 000262980500029 2-s2.0-58949103807 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article TANDEM MASS-SPECTROMETRY INTESTINAL OLIGOPEPTIDE TRANSPORTER LIQUID-CHROMATOGRAPHY MODEL PRODRUGS TRANSEPITHELIAL TRANSPORT FLAVONOL METABOLITES DIETARY FLAVONOIDS BETA-GLUCURONIDASE HUMAN PLASMA IDENTIFICATION Quercetin Prodrug Solubility Stability Permeability