이지숙 우경자 정혜선 2024-01-20T22:01:47Z 2024-01-20T22:01:47Z 2022-01-10 2009-02 2093-5552 https://pubs.kist.re.kr/handle/201004/132758 To overcome the stability problem of hydrophilic quantum dot (Q-dot), cellular uptake of hydrophobic instead of hydrophilic Q-dot was studied in the hope to find a simple method to use Q-dot as a cellular imaging probe. Hydrophobic Q-dot and poly-L-lactic acid (PLLA) were co-dissolved in chloroform to prepare stable films. Due to the cellular compatibility of PLLA, adherent cells were cultured on the film to observe the degree of Q-dot uptake and cytotoxicity of the prepared films. The results show that Q-dots were absorbed into NIH3T3 and EMT6 cells. Cellular uptake was also observed when hydrophobic Q-dots were coated directly on a glass plate. PLLA/Q-dot film and Q-dot coated on glass plate did not show major cytotoxicity. In vivo tumor model was also used to show the uptake of Q-dot from the PLLA/Q-dot film to the tumor site. Korean 한국약제학회 소수성 양자점을 함유한 Poly-L-Lactic Acid film의 제조 및 세포흡수 연구 Preparation and Cellular Uptake of Hydrophobic Quantum Dots Encapsulated in Poly-L-Lactic Acid Film Article 2 Journal of Pharmaceutical Investigation, v.39, no.1, pp.1 - 6 Journal of Pharmaceutical Investigation 39 1 1 6 kci ART001317121 Quantum-dot PLLA Cellular Uptake hydrophobic tumor imaging