Saravanakumar, Gurusamy Kim, Kwangmeyung Park, Jae Hyung Rhee, Kyehan Kwon, Ick Chan 2024-01-20T22:02:20Z 2024-01-20T22:02:20Z 2021-09-03 2009-02 1550-7033 https://pubs.kist.re.kr/handle/201004/132781 Endothelium plays a vital role in various vascular functions, and its dysfunction is a key underlying process closely related to diverse array of diseases such as atherosclerosis and tumor. Therefore, early detection of endothelial dysfunction at the functional or molecular level is of high importance for effective therapy. Recent advances in nanotechnology and our understanding in cellular and molecular biology have provided various biomedical imaging modalities and nanosized multimodal imaging agents. Multimodal nanoparticles that encompass the targeting ligands and magnetic/optical imaging labels enable us to visualize the pathophysiological process of various diseases using multiple imaging techniques. To visualize the specific pathogenic process at the molecular level, the imaging probe needs to be surface-functionalized with specific affinity ligands such as monoclonal antibodies (mAb). Combining the functional imaging agents along with therapeutic drugs has great potential for effective early detection, accurate diagnosis, and treatment of disease. The current review will highlight the application of various nanoparticle-based imaging agents and their recent developments in diagnosing endothelium dysfunction with a special emphasis on atherosclerosis and cancer. English AMER SCIENTIFIC PUBLISHERS SUPERPARAMAGNETIC IRON-OXIDE ADHESION MOLECULE-1 EXPRESSION IN-VIVO MAGNETIC-RESONANCE GOLD NANOPARTICLES CONTRAST AGENT QUANTUM DOTS ENDOTHELIAL DYSFUNCTION MULTIMODAL NANOPARTICLE TARGETED NANOPARTICLES Current Status of Nanoparticle-Based Imaging Agents for Early Diagnosis of Cancer and Atherosclerosis Article 10.1166/jbn.2009.030 1 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.5, no.1, pp.20 - 35 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 5 1 20 35 scie scopus 000263689500002 2-s2.0-67649813881 Nanoscience & Nanotechnology Materials Science, Biomaterials Science & Technology - Other Topics Materials Science Review SUPERPARAMAGNETIC IRON-OXIDE ADHESION MOLECULE-1 EXPRESSION IN-VIVO MAGNETIC-RESONANCE GOLD NANOPARTICLES CONTRAST AGENT QUANTUM DOTS ENDOTHELIAL DYSFUNCTION MULTIMODAL NANOPARTICLE TARGETED NANOPARTICLES Endothelial Angiogenesis Atherosclerosis Bioimaging Imaging Probes Nanoparticles