Cho, Sungsik Oh, Sangtae Um, Yumi Jung, Ji-Hee Ham, Jungyeob Shin, Woon-Seob Lee, Seokjoon 2024-01-20T22:02:55Z 2024-01-20T22:02:55Z 2021-09-03 2009-01-15 0960-894X https://pubs.kist.re.kr/handle/201004/132803 Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a-h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity. (C) 2008 Published by Elsevier Ltd. English PERGAMON-ELSEVIER SCIENCE LTD SOLUBLE DIHYDROARTEMISININ DERIVATIVES ANTIMALARIAL ACTIVITY DIFLUOROMETHYLENE KETONES CLICK CHEMISTRY DRUG GROWTH CYCLOADDITION INHIBITION ARTEETHER TOXICITY Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition Article 10.1016/j.bmcl.2008.11.067 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.2, pp.382 - 385 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19 2 382 385 scie scopus 000261908900020 2-s2.0-57849113145 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article SOLUBLE DIHYDROARTEMISININ DERIVATIVES ANTIMALARIAL ACTIVITY DIFLUOROMETHYLENE KETONES CLICK CHEMISTRY DRUG GROWTH CYCLOADDITION INHIBITION ARTEETHER TOXICITY Artemisinin Triazolyl artemisinin Huisgen 1,3-dipolar cylcoaddition Anticancer Natural product