Kang, Soo Sung Kim, Hyoung Ja Jin, Changbae Lee, Yong Sup 2024-01-20T22:03:15Z 2024-01-20T22:03:15Z 2021-09-03 2009-01-01 0960-894X https://pubs.kist.re.kr/handle/201004/132815 Melanogenesis is a physiological process that results in the production of melanin pigment. However, excessive accumulations of epidermal pigmentation can cause various hyperpigmentary disorders such as, melasma and age spots. Kojic acid and hydroxylated cinnamic acid derivatives are known to inhibit tyrosinase, a key component of melanin biosynthesis. Pyronyl-acrylic acid esters 3a-i, which share structural features of kojic acid and hydroxylated cinnamic acid, were prepared and their abilities to inhibit tyrosinase and melanin production were evaluated. Of the esters synthesized, 3e and 3h, which derived from diethylene glycol moieties were found to inhibit melanin production by ca. 20% at 20 mu g/ml, whereas kojic acid at 200 mu g/ml inhibited melanin production by 15.8%. (C) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD KOJIC ACID MELANOCYTE-TYROSINASE TOXICITY Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives Article 10.1016/j.bmcl.2008.10.119 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.1, pp.188 - 191 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19 1 188 191 scie scopus 000261908600041 2-s2.0-57749084378 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article KOJIC ACID MELANOCYTE-TYROSINASE TOXICITY Tyrosinase inhibitor Kojic acid Pyronyl Melanin production Skin-whitening