Yoon, Goo Zabriskie, T. Mark Cheon, Seung Hoon 2024-01-20T22:03:37Z 2024-01-20T22:03:37Z 2021-09-03 2009-01 0362-4803 https://pubs.kist.re.kr/handle/201004/132830 This report describes an efficient method of synthesizing [guanido-C-13]-gamma-hydroxyarginine HCl salt. Iodolactonization of N-Boc-protected allylglycine mainly provided the cis iodo compound 2. This was converted to an amine through azide 4. The amine 5 was reacted with N-Boc-protected [C-13)thiourea to afford N-Boc-protected [C-13]guanidine 6, which underwent base catalyzed ring opening. Removal of the N-Boc group afforded [guanido-C-13]-gamma-hydroxyarginine HCl salt 7 giving a 30% overall yield of the final product from N-Boc protected allylglycine 1 in five steps. English WILEY AMINO-ACIDS IN-VITRO ENDURACIDIN VIVO MINOSAMINOMYCIN Synthesis of [guanido-C-13]-gamma-hydroxyarginine Article 10.1002/jlcr.1570 1 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, v.52, no.1-2, pp.53 - 55 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 52 1-2 53 55 scie scopus 000263985000008 2-s2.0-62849093371 Biochemical Research Methods Chemistry, Medicinal Chemistry, Analytical Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article AMINO-ACIDS IN-VITRO ENDURACIDIN VIVO MINOSAMINOMYCIN carbon-13 synthesis [guanido-C-13]-gamma-hydroxyarginine iodolactonization