Roy, R. K. Choi, H. W. Yi, J. W. Moon, M. -W. Lee, K. -R. Han, D. K. Shin, J. H. Kamijo, A. Hasebe, T. 2024-01-20T22:04:02Z 2024-01-20T22:04:02Z 2021-09-03 2009-01 1742-7061 https://pubs.kist.re.kr/handle/201004/132847 The hemocompatibility of plasma-treated, silicon-incorporated, diamond-like carbon (Si-DLC) films was investigated. Si-DLC films with a Si concentration of 2 at.% were prepared on Si (100) or Nitinol substrates using a capacitively coupled radiofrequency plasma-assisted chemical vapor deposition method using a mixed gas of benzene (C6H6) and diluted silane (SiH4:H-2 = 10:90). The Si-DLC films were then treated with O-2, CF4 or N-2 glow discharge for surface modification. The plasma treatment revealed an intimate relationship between the polar component of the surface energy and its hemocompatibility. All in vitro characterizations, i.e. protein absorption behavior, activated partial thromboplastin time measurement and platelet adhesion behavior, showed improved hemocompatibility of the N-2- or O-2-plasma-treated surfaces where the polar component of the surface energy was significantly increased. Si-O or Si-N surface bonds played an important role in improving hemocompatibility, as observed in a model experiment. These results support the importance of a negatively charged polar component of the surface in inhibiting fibrinogen adsorption and platelet adhesion. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD PROTEIN ADSORPTION AMORPHOUS-CARBON DLC COATINGS PLATELET ACTIVATION ENERGY BIOCOMPATIBILITY THROMBOGENICITY ATTACHMENT INTERFACES FIBRINOGEN Hemocompatibility of surface-modified, silicon-incorporated, diamond-like carbon films Article 10.1016/j.actbio.2008.07.031 1 ACTA BIOMATERIALIA, v.5, no.1, pp.249 - 256 ACTA BIOMATERIALIA 5 1 249 256 scie scopus 000261922400026 2-s2.0-56349139477 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article PROTEIN ADSORPTION AMORPHOUS-CARBON DLC COATINGS PLATELET ACTIVATION ENERGY BIOCOMPATIBILITY THROMBOGENICITY ATTACHMENT INTERFACES FIBRINOGEN Diamond-like carbon Surface treatment Hemocompatibility Polar component Platelet adhesion