Lee, Yeo Ran Kim, Dong Jin Mook-Jung, Inhee Yoo, Kyung Ho 2024-01-20T22:04:44Z 2024-01-20T22:04:44Z 2021-09-03 2008-12-20 0253-2964 https://pubs.kist.re.kr/handle/201004/132873 A series of thiazolo[5,4-b]pydine and oxazolo[5,4-b]pyridine derivatives 1a-o were designed. These fifteen compounds were evaluated by A/beta 42 fibril formation inhibitory assay using thioflavin T as a dye. Thiazolo[5,4-b]pyridines 1a-g showed potent inhibitory activities for A beta 42 fibrillization at IC50 of 0.23-4.5 mu M. Among them, compounds 1b and 1k having methoxy group at C-5 exhibited excellent activities (IC50 = 0.23 and 0.50 mu M, respectively) than that of Curcumin (IC50 = 0.80 mu M). English WILEY-V C H VERLAG GMBH ALZHEIMERS-DISEASE FIBRIL FORMATION PROTEIN PLAQUES CYCLIZATION Synthesis of Thia(oxa)zolopyridines and Their Inhibitory Activities for beta-Amyloid Fibrillization Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.29, no.12, pp.2331 - 2336 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 29 12 2331 2336 scie scopus kci ART001525754 000262397500005 2-s2.0-60149107662 Chemistry, Multidisciplinary Chemistry Article ALZHEIMERS-DISEASE FIBRIL FORMATION PROTEIN PLAQUES CYCLIZATION Alzheimer&apos s disease beta-Amyloid fibrillization Thia(oxa)zolopyridines Binding affinity