Cha, Sun-Shin Il Jung, Ha Jeon, Hyesung An, Young Jun Kim, In-Kwon Yun, Sanguk Ahn, Hyun Jin Chung, Kwang Chul Lee, Sang Hee Suh, Pann-Ghill Kang, Sa-Ouk 2024-01-20T22:04:58Z 2024-01-20T22:04:58Z 2021-09-03 2008-12-05 0021-9258 https://pubs.kist.re.kr/handle/201004/132883 Mutations in the DJ-1 gene have been implicated in the autosomal recessive early onset parkinsonism. DJ-1 is a soluble dimeric protein with critical roles in response to oxidative stress and in neuronal maintenance. However, several lines of evidence suggest the existence of a nonfunctional aggregated form of DJ-1 in the brain of patients with some neurodegenerative diseases. Here, we show that inorganic phosphate, an important anion that exhibits elevated levels in patients with Parkinson disease, transforms DJ-1 into filamentous aggregates. According to the 2.4-angstrom crystal structure, DJ-1 dimers are linearly stacked through P-i-mediated interactions to form protofilaments, which are then bundled into a filamentous assembly. English AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC FAMILIAL PARKINSONS-DISEASE MULTIPLE SYSTEM ATROPHY OXIDATIVE STRESS DROSOPHILA DJ-1 ALPHA-SYNUCLEIN PROTEIN DJ-1 CELL-DEATH FERTILITY L166P INACTIVATION Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner Article 10.1074/jbc.M804243200 1 JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.49, pp.34069 - 34075 JOURNAL OF BIOLOGICAL CHEMISTRY 283 49 34069 34075 scie scopus 000261277700035 2-s2.0-57749116309 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article FAMILIAL PARKINSONS-DISEASE MULTIPLE SYSTEM ATROPHY OXIDATIVE STRESS DROSOPHILA DJ-1 ALPHA-SYNUCLEIN PROTEIN DJ-1 CELL-DEATH FERTILITY L166P INACTIVATION *2008년도 개인평가에 반영되었음