Jung, Myung-Ho Oh, Chang-Hyun 2024-01-20T22:30:37Z 2024-01-20T22:30:37Z 2021-08-31 2008-11-20 0253-2964 https://pubs.kist.re.kr/handle/201004/132974 The synthesis of a new series of diaryl ureas having a pyrrolo[2,3-d]pyrimidine scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. The para substituted compounds la-g showed superior or similiar activity to Sorafenib against the A375 cell line. Among these compounds, Ic-e showed excellent activity against 375 compared with Sorafenib, a multi-kinase inhibitor. English WILEY-V C H VERLAG GMBH REFRACTORY SOLID TUMORS FACTOR RECEPTOR INHIBITOR RAF KINASE INHIBITORS PHASE-I BAY-43-9006 PHARMACOKINETICS THERAPY PATHWAY SAFETY UREAS Synthesis and Antiproliferative Activities of Pyrrolo[2,3-d]pyrimidine Derivatives for Melanoma Cell Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.29, no.11, pp.2231 - 2236 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 29 11 2231 2236 scie scopus kci ART001525660 000262091500029 2-s2.0-57349106093 Chemistry, Multidisciplinary Chemistry Article REFRACTORY SOLID TUMORS FACTOR RECEPTOR INHIBITOR RAF KINASE INHIBITORS PHASE-I BAY-43-9006 PHARMACOKINETICS THERAPY PATHWAY SAFETY UREAS Pyrrolo[2,3-d]pyrimidine A375 Antiproliferative activity