Choi, Hyun-Sik Kim, Hyoung Ja Nam, Sang-Gil Kim, In-Seon Lee, Kyung-Tae Yook, Chang-Soo Lee, Yong Sup 2024-01-20T22:32:14Z 2024-01-20T22:32:14Z 2021-08-31 2008-11 0009-2363 https://pubs.kist.re.kr/handle/201004/133036 Three new lupane-type saponins, acankoreosides F-H (1-3) were isolated from the methanol extract of the leaves of Acanthopanax koreanum NAKAI. The structures of these three saponins were established by chemical and spectroscopic analysis as 3 alpha,30-dihydroxylup-20(29)-en-23,28-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyransoyl] ester (2), and (20S) 3 alpha-hydroxylup-23-al-28,29-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl] ester (3), respectively. The effects of the isolates (1-3) on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E-2 were evaluated in RAW 264.7 macrophages. English PHARMACEUTICAL SOC JAPAN NFAT TRANSCRIPTION FACTOR TRITERPENE GLYCOSIDES SCHEFFLERA-OCTOPHYLLA TNF-ALPHA DITERPENOIDS SECRETION LICHENS FUNGI CELLS ACID Lupane Glycosides from the Leaves of Acanthopanax koreanum Article 10.1248/cpb.56.1613 1 CHEMICAL & PHARMACEUTICAL BULLETIN, v.56, no.11, pp.1613 - 1616 CHEMICAL & PHARMACEUTICAL BULLETIN 56 11 1613 1616 scie scopus 000260521600020 2-s2.0-55749085598 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article NFAT TRANSCRIPTION FACTOR TRITERPENE GLYCOSIDES SCHEFFLERA-OCTOPHYLLA TNF-ALPHA DITERPENOIDS SECRETION LICHENS FUNGI CELLS ACID Acanthopanax koreanum Araliaceae lupane glycoside acankoreoside