Kim, Hye-Jung Yu, Myeong-Hee Kim, Hoguen Byun, Jonghoe Lee, Cheoju 2024-01-20T22:32:26Z 2024-01-20T22:32:26Z 2021-08-31 2008-10-31 1976-6696 https://pubs.kist.re.kr/handle/201004/133043 Colorectal cancer (CRC) is the third most common malignancy in the world. Because CRC develops slowly from removable precancerous lesions, detection of the disease at an early stage during regular health examinations can reduce both the incidence and mortality of the disease. Although sigmoidoscopy offers significant improvements in the detection rate of CRC, its diagnostic value is limited by its high costs and inconvenience. Therefore, there is a compelling need for the identification of noninvasive biomarkers that can enable earlier detection of CRC. Accordingly, many validation studies have been conducted to evaluate genetic, epigenetic or protein markers that can be detected in the stool or in serum. Currently, the fecal-occult blood test is the most widely used method of screening for CRC. However, advances in genomics and proteomics combined with developments in other relevant fields will lead to the discovery of novel non invasive biomarkers whose usefulness will be tested in larger validation studies. Here, noninvasive molecular biomarkers that are currently used in clinical settings and have the potential for use as CRC biomarkers are discussed. [BMB reports 2008; 41(10): 685-692] English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY FECAL-OCCULT-BLOOD ABERRANT CRYPT FOCI SERUM TUMOR-MARKER COLON-CANCER TISSUE INHIBITOR K-RAS POTENTIAL MARKER DNA METHYLATION EUROPEAN GROUP P53 MUTATIONS Noninvasive molecular biomarkers for the detection of colorectal cancer Article 10.5483/BMBRep.2008.41.10.685 1 BMB REPORTS, v.41, no.10, pp.685 - 692 BMB REPORTS 41 10 685 692 scie scopus kci ART001287517 000260569500001 2-s2.0-55249090218 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Review FECAL-OCCULT-BLOOD ABERRANT CRYPT FOCI SERUM TUMOR-MARKER COLON-CANCER TISSUE INHIBITOR K-RAS POTENTIAL MARKER DNA METHYLATION EUROPEAN GROUP P53 MUTATIONS Biomarker Colorectal cancer Early detection Fecal-occult blood test Noninvasive marker Proteomics