Kwon, Taeyun Eom, Kilho Park, Jinsung Yoon, Dae Sung Lee, Hong Lim Kim, Tae Song 2024-01-20T22:32:29Z 2024-01-20T22:32:29Z 2021-09-03 2008-10-27 0003-6951 https://pubs.kist.re.kr/handle/201004/133045 Resonant microcantilevers have recently enabled the label-free detection of biomolecules. Here, we observed the kinetics of biomolecular interactions such as antigen-antibody interactions and/or DNA hybridization based on a resonant frequency shift, obeying Langmuir kinetics, measured in a buffer solution. It is shown that the kinetics of DNA adsorptions on the surface is governed by intermolecular interactions between adsorbed DNA molecules. It is also shown that the kinetics of DNA hybridization is determined by the intermolecular interaction. It is implied that resonant microcantilever in buffer solution may allow for gaining insights into the kinetics of various molecular interactions. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.3006329] English AMER INST PHYSICS DNA HYBRIDIZATION LIQUID FLUID Micromechanical observation of the kinetics of biomolecular interactions Article 10.1063/1.3006329 1 APPLIED PHYSICS LETTERS, v.93, no.17 APPLIED PHYSICS LETTERS 93 17 scie scopus 000260571800099 2-s2.0-55149102227 Physics, Applied Physics Article DNA HYBRIDIZATION LIQUID FLUID