Lee, Ji Hoon Byeon, Seong Rim Kim, YoungSoo Lim, Soo Jeong Oh, Seung Jun Moon, Dae Hyuk Yoo, Kyung Ho Chung, Bong Young Kim, Dong Jin 2024-01-20T22:32:35Z 2024-01-20T22:32:35Z 2021-09-03 2008-10-15 0960-894X https://pubs.kist.re.kr/handle/201004/133049 In this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for beta-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [I-125]TZDM against beta-amyloid 1-42 (A beta 42) aggregates. Two new [F-18]-labeled isoindole derivatives were synthesized and evaluated as potential beta-amyloid imaging probes based on the in vivo pharmacokinetic profiles. The preliminary results suggest that these [F-18]18b and [F-18]18c are promising positron emission tomography (PET) imaging probes for studying accumulation of A beta fibrils in the brains of Alzheimer's disease (AD) patients. (C) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ALZHEIMERS-DISEASE NEUROFIBRILLARY TANGLES PLAQUES MEDICINE BINDING [F-18]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils Article 10.1016/j.bmcl.2008.05.019 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5701 - 5704 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18 20 5701 5704 scie scopus 000259972800083 2-s2.0-53549126618 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ALZHEIMERS-DISEASE NEUROFIBRILLARY TANGLES PLAQUES MEDICINE BINDING Alzheimer&apos s disease [F-18]-labeled PET imaging probe