Byun, Ji Hun Kim, HyeYun Kim, YoungSoo Mook-Jung, Inhee Kim, Dong Jin Lee, Won Koo Yoo, Kyung Ho 2024-01-20T22:32:37Z 2024-01-20T22:32:37Z 2021-09-03 2008-10-15 0960-894X https://pubs.kist.re.kr/handle/201004/133050 The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for A beta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for A beta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50) = 0.07 and 0.08 mu M, respectively) than those of Curcumin (IC(50) = 0.80 mu M) and IMSB (IC(50) = 8.00 mu M) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. (C) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ALZHEIMERS-DISEASE AMYLOID PLAQUES IMAGING AGENTS PROTEIN PROBES BRAIN Aminostyrylbenzofuran derivatives as potent inhibitors for A beta fibril formation Article 10.1016/j.bmcl.2008.08.111 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5591 - 5593 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18 20 5591 5593 scie scopus 000259972800056 2-s2.0-53349147027 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ALZHEIMERS-DISEASE AMYLOID PLAQUES IMAGING AGENTS PROTEIN PROBES BRAIN Alzheimer&apos s disease A beta 42 fibrils aminostyrylbenzofurans inhibitory activity