Choe, Yun Jeong Seo, Han Na Jung, Soo Yeon Rhim, Hyewhon Kim, Jungahn Choo, Dong Joon Lee, Jae Yeol 2024-01-20T22:34:17Z 2024-01-20T22:34:17Z 2021-09-03 2008-10 0365-6233 https://pubs.kist.re.kr/handle/201004/133121 3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R-1, a biphenyl group at R-2, and a benzyl amido group at R-3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of Q (KYS05090). English WILEY-V C H VERLAG GMBH DERIVATIVES ALPHA(1G) RELEASE MUSCLE ACID Synthesis and SAR Study of T-Type Calcium Channel Blockers. Part II Article 10.1002/ardp.200800079 1 ARCHIV DER PHARMAZIE, v.341, no.10, pp.661 - 664 ARCHIV DER PHARMAZIE 341 10 661 664 scie scopus 000260436300007 2-s2.0-53549106616 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article DERIVATIVES ALPHA(1G) RELEASE MUSCLE ACID Blockers 3,4-Dihydroquinazoline SAR study T-type calcium channel