Kim, Jae In Eom, Kilho Kwak, Moon Kyu Na, Sungsoo 2024-01-20T22:34:20Z 2024-01-20T22:34:20Z 2021-09-03 2008-10 1546-2218 https://pubs.kist.re.kr/handle/201004/133124 This paper concerns the application of component mode synthesis for biomolecule modeling to understand protein dynamics. As for protein dynamics, eigenvalue problem should be formulated to obtain eigenvalue, eigenvector and thermal fluctuation. To describe the thermal fluctuation of protein, normal mode analysis is introduced and normal modes identify the dynamic behavior of protein very well. Component mode synthesis considers the given complex structure as ail assembly of smaller components. The selection of a component may be arbitrary. When the component mode synthesis is applied to formulate the eigenvalue problem of protein structure, we selected a protein which may be composed of two and/or four domains. The domain of protein can be considered as it component. In this sense the number of component is increased as necessary, and the size of each component is decreased for fast calculation. The component mode synthesis widely used in engineering was well applied to understand protein dynamics in present Study. English TECH SCIENCE PRESS Application of Component Mode Synthesis to Protein Structure for Dynamic Analysis Article 1 CMC-COMPUTERS MATERIALS & CONTINUA, v.8, no.2, pp.67 - 73 CMC-COMPUTERS MATERIALS & CONTINUA 8 2 67 73 scie scopus 000260915000002 2-s2.0-58149402034 Computer Science, Information Systems Materials Science, Multidisciplinary Computer Science Materials Science Article Component mode synthesis normal mode analysis eigenvalue problem protein thermal fluctuation