Heo, Jae Ho Seo, Han Na Choe, Yun Jeong Kim, Sujin Oh, Chun Rim Kim, Young Deuk Rhim, Hyewhon Choo, Dong Joon Kim, Jungahn Lee, Jae Yeol 2024-01-20T23:02:15Z 2024-01-20T23:02:15Z 2021-09-03 2008-07-15 0960-894X https://pubs.kist.re.kr/handle/201004/133320 In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment. (C) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD BIOLOGICAL EVALUATION CALCIUM-CHANNELS IN-VITRO INHIBITION PROLIFERATION MIBEFRADIL EXPRESSION DRUG T-type Ca2+ channel blockers suppress the growth of human cancer cells Article 10.1016/j.bmcl.2008.06.034 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.14, pp.3899 - 3901 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18 14 3899 3901 scie scopus 000257640400014 2-s2.0-47249156681 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article BIOLOGICAL EVALUATION CALCIUM-CHANNELS IN-VITRO INHIBITION PROLIFERATION MIBEFRADIL EXPRESSION DRUG T-type calcium channel blocker 3,4-dihydroquinazoline doxorubicin anti-cancer