Kim, Juhyun Jung, Sang-Yong Lee, Yeon Kyung Park, Sangki Choi, June-Seek Lee, C. Justin Kim, Hye-Sun Choi, Yun-Beom Scheiffele, Peter Bailey, Craig H. Kandel, Eric R. Kim, Joung-Hun 2024-01-20T23:02:22Z 2024-01-20T23:02:22Z 2021-09-03 2008-07-01 0027-8424 https://pubs.kist.re.kr/handle/201004/133326 Neuroligin-1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. Despite evidence for the role of neuroligin-1 in specifying excitatory synapses, the underlying molecular mechanisms and physiological consequences that neuroligin-1 may have at mature synapses of normal adult animals remain unknown. By silencing endogenous neuroligin-1 acutely in the amygdala of live behaving animals, we have found that neuroligin-1 is required for the storage of associative fear memory. Subsequent cellular physiological studies showed that suppression of neuroligin-1 reduces NMDA receptor-mediated currents and prevents the expression of long-term potentiation without affecting basal synaptic connectivity at the thalamo-amygdala pathway. These results indicate that persistent expression of neuroligin-1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals. English NATL ACAD SCIENCES LONG-TERM POTENTIATION SYNAPTIC-TRANSMISSION INHIBITORY SYNAPSES ADHESION MOLECULE LATERAL AMYGDALA AUTISM PLASTICITY MODULATION MUTATION PATHWAY Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals Article 10.1073/pnas.0803448105 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.105, no.26, pp.9087 - 9092 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 26 9087 9092 scie scopus 000257354400052 2-s2.0-48249156612 Multidisciplinary Sciences Science & Technology - Other Topics Article LONG-TERM POTENTIATION SYNAPTIC-TRANSMISSION INHIBITORY SYNAPSES ADHESION MOLECULE LATERAL AMYGDALA AUTISM PLASTICITY MODULATION MUTATION PATHWAY synaptic plasticity neuroligin autism