유경호 이여란 2024-01-20T23:04:44Z 2024-01-20T23:04:44Z 2021-09-06 2008-06 1225-9098 https://pubs.kist.re.kr/handle/201004/133442 The central role of tyrosine phosphorylation in cell proliferative signalingmechanisms provides another target for chemotherapy. The aim of this research is to develop new quinazoline derivatives that poses the inhibitory activit receptor (EGFR) tyrosine kinase (TK) as protein kinase inhibitors. In this work, a series of new 4-anilino-6-guanidino-7-methoxyquinazoline derivatives ( 12a-l ) were synthesized by the introduction of guanidine moiety at C-6 of quinazoline nucleus TK inhibitory activities. Korean 한국응용과학기술학회 6-구아니디노퀴나졸린 유도체의 합성 및EGFR 저해 활성 Synthesis and EGFR Inhibitory Activity of6-Guanidinoquinazoline Derivatives Article 2 한국응용과학기술학회지, v.25, no.2, pp.240 - 251 한국응용과학기술학회지 25 2 240 251 kci ART001263947 quinazolines synthesis EGFR TK inhibitory activity