Lee, Saet Byoul Lee, Joo Young Song, Dae-Geun Pan, Cheol-Ho Nho, Chu Won Kim, Min Cheol Lee, Eun Ha Jung, Sang Hoon Kim, Hyung-Seop Kim, Yeong Shik Um, Byung Hun 2024-01-20T23:04:54Z 2024-01-20T23:04:54Z 2021-09-03 2008-06 1226-7708 https://pubs.kist.re.kr/handle/201004/133450 Cancer chemopreventive effects can be exerted through the induction of phase 11 detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflannnatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Culteria cylindrica exhibited the high cherrioprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at 100 mu g/mL by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desinarestia ligulala, Desmarestia viridis, Dictyopleris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production in a dose-dependant manner in 5-20 mu g/mL. These seaweed extracts could be used as food materials for cancer chenioprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and PGE2 production. English KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST NITRIC-OXIDE TRANSCRIPTIONAL REGULATION PHENOLIC ANTIOXIDANTS INDUCIBLE EXPRESSION GENE COX-2 INFLAMMATION MACROPHAGES MECHANISMS RECEPTORS Cancer chemopreventive effects of Korean seaweed extracts Article 1 FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.3, pp.613 - 622 FOOD SCIENCE AND BIOTECHNOLOGY 17 3 613 622 scie scopus kci ART001264335 000257488700028 2-s2.0-49649095422 Food Science & Technology Food Science & Technology Article NITRIC-OXIDE TRANSCRIPTIONAL REGULATION PHENOLIC ANTIOXIDANTS INDUCIBLE EXPRESSION GENE COX-2 INFLAMMATION MACROPHAGES MECHANISMS RECEPTORS quinone reductase cheinoprevention index detoxification enzyme antioxidant response element anti-inflammation