Suresh, Babu C., V Babar, Sheikh Md. Enayetul Song, Eun Joo Oh, Eulsik Yoo, Young Sook 2024-01-20T23:05:24Z 2024-01-20T23:05:24Z 2022-01-10 2008-05-31 1016-8478 https://pubs.kist.re.kr/handle/201004/133475 Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently. English KOREAN SOC MOLECULAR & CELLULAR BIOLOGY ACTIVATED PROTEIN-KINASE EPIDERMAL-GROWTH-FACTOR SYSTEMS BIOLOGY PHOSPHATASE 2A REGULATED KINASES RAF AKT RECEPTOR MECHANISM 3-KINASE Kinetic analysis of the MAPK and PI3K/Akt signaling pathways Article 1 MOLECULES AND CELLS, v.25, no.3, pp.397 - 406 MOLECULES AND CELLS 25 3 397 406 scie scopus kci ART001259440 000256486000010 2-s2.0-51049097954 Biochemistry & Molecular Biology Cell Biology Biochemistry & Molecular Biology Cell Biology Article ACTIVATED PROTEIN-KINASE EPIDERMAL-GROWTH-FACTOR SYSTEMS BIOLOGY PHOSPHATASE 2A REGULATED KINASES RAF AKT RECEPTOR MECHANISM 3-KINASE biochemical pathway computational modeling MAPK PI3K/Akt signal transduction systems biology