Na, Heung Sik Choi, Soonwook Kim, Junesun Park, Joonoh Shin, Hee-Sup 2024-01-20T23:31:23Z 2024-01-20T23:31:23Z 2021-09-03 2008-04-30 1016-8478 https://pubs.kist.re.kr/handle/201004/133544 To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Ca(V)3.1 (alpha(-/-)(1G)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The a(1G)(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of alpha(1G) subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia. English KOREAN SOC MOLECULAR & CELLULAR BIOLOGY DORSAL-ROOT GANGLION NERVE INJURY CA2+ CHANNELS CALCIUM-CHANNELS SENSORY NEURONS MECHANICAL ALLODYNIA THERMAL HYPERALGESIA TACTILE ALLODYNIA RAT MODEL PLASTICITY Attenuated neuropathic pain in Ca(V)3.1 null mice Article 1 MOLECULES AND CELLS, v.25, no.2, pp.242 - 246 MOLECULES AND CELLS 25 2 242 246 scie scopus kci ART001235405 000255901600013 2-s2.0-44949169576 Biochemistry & Molecular Biology Cell Biology Biochemistry & Molecular Biology Cell Biology Article DORSAL-ROOT GANGLION NERVE INJURY CA2+ CHANNELS CALCIUM-CHANNELS SENSORY NEURONS MECHANICAL ALLODYNIA THERMAL HYPERALGESIA TACTILE ALLODYNIA RAT MODEL PLASTICITY allodynia central sensitization hyperalgesia spinal nerve ligation (SNL) T-type calcium channel