Um, Yumi Cho, Sungsik Woo, Ho Bum Kim, Yong Kee Kim, Hanna Ham, Jungyeob Kim, Su-Nam Ahn, Chan Mug Lee, Seokjoon 2024-01-20T23:31:47Z 2024-01-20T23:31:47Z 2021-09-03 2008-04-01 0968-0896 https://pubs.kist.re.kr/handle/201004/133564 In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells. (C) 2008 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD P-GLYCOPROTEIN BIOLOGICAL EVALUATION CANCER-CELLS DERIVATIVES ANTICANCER MODULATION INHIBITION THERAPY ANALOGS AGENTS Synthesis of curcumin mimics with multidrug resistance reversal activities Article 10.1016/j.bmc.2008.02.012 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.7, pp.3608 - 3615 BIOORGANIC & MEDICINAL CHEMISTRY 16 7 3608 3615 scie scopus 000255245900014 2-s2.0-41649097357 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article P-GLYCOPROTEIN BIOLOGICAL EVALUATION CANCER-CELLS DERIVATIVES ANTICANCER MODULATION INHIBITION THERAPY ANALOGS AGENTS curcumin curcumin mimics multidrug resistance multidrug resistance reversal activities anticancer