Park, Sangkyu Yoon, Euisung Lee, Sukchan Shin, Hee-sup Park, Hyunjun Kim, Byungkyu Kim, Daesoo Park, Jongoh Park, Sukho 2024-01-20T23:32:22Z 2024-01-20T23:32:22Z 2021-09-03 2008-04 0964-1726 https://pubs.kist.re.kr/handle/201004/133593 A hand-controlled microdrive has been used to obtain neural signals from rodents such as rats and mice. However, it places severe physical stress on the rodents during its manipulation, and this stress leads to alertness in the mice and low efficiency in obtaining neural signals from the mice. To overcome this issue, we developed a novel microdrive, which allows one to adjust the electrodes by a piezoelectric device (PZT) with high precision. Its mass is light enough to install on the mouse's head. The proposed microdrive has three H-type PZT actuators and their guiding structure. The operation principle of the microdrive is based on the well known inchworm mechanism. When the three PZT actuators are synchronized, linear motion of the electrode is produced along the guiding structure. The electrodes used for the recording of the neural signals from neuron cells were fixed at one of the PZT actuators. Our proposed microdrive has an accuracy of about 400 nm and a long stroke of about 5 mm. In response to formalin-induced pain, single unit activities are robustly measured at the thalamus with electrodes whose vertical depth is adjusted by the microdrive under urethane anesthesia. In addition, the microdrive was efficient in detecting neural signals from mice that were moving freely. Thus, the present study suggests that the PZT-based microdrive could be an alternative for the efficient detection of neural signals from mice during behavioral states without any stress to the mice. English IOP PUBLISHING LTD MOTORIZED MICRODRIVE LINEAR PIEZOMOTOR HIGH STIFFNESS CORTEX MICROELECTRODES The development of a PZT-based microdrive for neural signal recording Article 10.1088/0964-1726/17/2/027001 1 SMART MATERIALS AND STRUCTURES, v.17, no.2 SMART MATERIALS AND STRUCTURES 17 2 scie scopus 000254176300040 2-s2.0-43249121923 Instruments & Instrumentation Materials Science, Multidisciplinary Instruments & Instrumentation Materials Science Article MOTORIZED MICRODRIVE LINEAR PIEZOMOTOR HIGH STIFFNESS CORTEX MICROELECTRODES neural signal recording microdrive PZT