El-Deeb, Ibrahim Mustafa Ryu, Jae Chun Lee, So Ha 2024-01-20T23:33:08Z 2024-01-20T23:33:08Z 2021-08-31 2008-04 1420-3049 https://pubs.kist.re.kr/handle/201004/133629 New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tert-butoxide in refluxing toluene under a nitrogen atmosphere. The target N-aryl derivatives were obtained in moderate to good yields ranging from 27% to 82%. The procedure described could be widely employed for the preparation of new heterocyclic compounds. The structures of the new compounds were confirmed by FT-NMR, FT-IR and elemental analysis. English MDPI PYRIMIDINE INHIBITORS IMATINIB Synthesis of new N-arylpyrimidin-2-amine derivatives using a palladium catalyst Article 10.3390/molecules13040818 1 MOLECULES, v.13, no.4, pp.818 - 830 MOLECULES 13 4 818 830 scie scopus 000255515900013 2-s2.0-43049135154 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article PYRIMIDINE INHIBITORS IMATINIB palladium catalyst N-arylation aminopyrimidine xantphos Suzuki coupling Buchwald-Hartwig amination