김성규 함인혜 부영민 김호철 조정혁 최호영 2024-01-20T23:34:23Z 2024-01-20T23:34:23Z 2021-09-06 2008-03 1229-1765 https://pubs.kist.re.kr/handle/201004/133688 Objectives : This study was to verify the Attributive Channel theory of herbal medicine.Methods : [131I]iodohesperetin was synthesized, separated, and refined from hesperetin, the major component of Citrus species, followed by observing the biodistribution in an organism of C57 BL/6 mice with and without Lewis Lung Carcinoma.Results : Iodohesperetin 27.5 mg was obtained through column chromatography after a reaction with 50 mg of Hesperitin and 8 mg of NaI. The radiochemical yield of [131I]iodohesperetin synthesis was 25 % when checked with Radio TLC chromatography. [131I]iodohesperetin was most largely distributed in the stomach, lung and liver of C57BL/6 mouse. The highest %ID/g in stomach was 40 min, in lung and liver was 20 min after injection. The % ID/g of tumor tissue was comparable with that of blood.Conclusions : The fact that [131I]iodocurcumin was most largely distributed in the stomach, lung and liver was related with the Attributive Channel theory. And there was no significant finding related to tumor cells. Korean 대한본초학회 Hesperetin의 I-131 표지 및 生體 分布 分析을 통한 歸經 연구 Study on the Attributive Channel Theory of Herbal Medicine by the Pharmacodynamic Research of I-131 Labelled Hesperetin Article 2 대한본초학회지, v.23, no.1, pp.117 - 125 대한본초학회지 23 1 117 125 kci ART001242913 Attributive Channel I-131 Hesperetin biodistribution Attributive Channel I-131 Hesperetin biodistribution