Oh, Chang Hyun Hong, Joon Hee 2024-01-21T00:01:14Z 2024-01-21T00:01:14Z 2021-09-02 2008-02 1525-7770 https://pubs.kist.re.kr/handle/201004/133799 This article describes an efficient route for synthesizing novel cyclopropyl homologous PMEA analogues. The condensation of the bromide 8 with nucleosidic bases (A, U, T, C, 5-FU, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid analogues 14 similar to 18 and 21. These compounds were evaluated for their potential antiviral properties against various viruses. Guanine derivative 21 showed significant antiviral activity. English TAYLOR & FRANCIS INC HUMAN-IMMUNODEFICIENCY-VIRUS DNA VIRUS PHOSPHONYLMETHOXYALKYLPYRIMIDINES NUCLEOSIDES AGENTS Design, synthesis and anti-HIV activity of homologous PMEA derivatives Article 10.1080/15257770701795953 1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.27, no.2, pp.186 - 195 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 27 2 186 195 scie scopus 000252516500008 2-s2.0-38349127672 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article HUMAN-IMMUNODEFICIENCY-VIRUS DNA VIRUS PHOSPHONYLMETHOXYALKYLPYRIMIDINES NUCLEOSIDES AGENTS homologous PMEA acyclic nucleoside antiviral agent