Park, Jae Hyung Lee, Seulki Kim, Jong-Ho Park, Kyeongsoon Kim, Kwangmeyung Kwon, Ick Chan 2024-01-21T00:02:21Z 2024-01-21T00:02:21Z 2021-09-02 2008-01 0079-6700 https://pubs.kist.re.kr/handle/201004/133851 Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines. (c) 2007 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD SELF-ASSEMBLED NANOPARTICLES ACCELERATED BLOOD CLEARANCE BLOCK-COPOLYMER MICELLES MODIFIED GLYCOL CHITOSAN GENE DELIVERY SYSTEM LOW-MOLECULAR-WEIGHT IN-VIVO POLY(ETHYLENE GLYCOL) PLASMID DNA TRANSFECTION EFFICIENCY Polymeric nanomedicine for cancer therapy Article 10.1016/j.progpolymsci.2007.09.003 1 PROGRESS IN POLYMER SCIENCE, v.33, no.1, pp.113 - 137 PROGRESS IN POLYMER SCIENCE 33 1 113 137 scie scopus 000253143900003 2-s2.0-37249068568 Polymer Science Polymer Science Review SELF-ASSEMBLED NANOPARTICLES ACCELERATED BLOOD CLEARANCE BLOCK-COPOLYMER MICELLES MODIFIED GLYCOL CHITOSAN GENE DELIVERY SYSTEM LOW-MOLECULAR-WEIGHT IN-VIVO POLY(ETHYLENE GLYCOL) PLASMID DNA TRANSFECTION EFFICIENCY polymeric nanomedicine cancer therapy angiogenesis targeted delivery drug carrier