Kim, Jeansok J. Lee, Hongjoo J. Welday, Adam C. Song, EunYoung Cho, Jeiwon Sharp, Patricia E. Jung, Min W. Blair, Hugh T. 2024-01-21T00:05:03Z 2024-01-21T00:05:03Z 2021-09-02 2007-11-13 0027-8424 https://pubs.kist.re.kr/handle/201004/133977 Acute, inescapable, and unpredictable stress can profoundly modify brain and cognition in humans and animals. The present study investigated the ensuing effects of 2-h variable "audiogenic" stress on three related levels of hippocampal functions in rats: long-term potentiation, place cell activity, and spatial memory. In agreement with prior findings, we observed that stress reduced the magnitude of Schaffer collateral/commissural-Cornu Ammonis field 1 long-term potentiation in vitro, and selectively impaired spatial memory on a hidden platform version of the Morris water maze task. We also observed that stress impaired the stability of firing rates (but not firing locations) of place cells recorded from dorsal Cornu Ammonis field 1 in rats foraging freely on a novel open-field platform located in a familiar surrounding room. These findings suggest that stress-induced modifications in synaptic plasticity may prevent the storage of stable "rate maps" by hippocampal place cells, which in turn may contribute to spatial memory impairments associated with stress. English NATL ACAD SCIENCES LONG-TERM POTENTIATION BEHAVIORAL STRESS SYNAPTIC PLASTICITY DECLARATIVE MEMORY AUDIOGENIC STRESS DENTATE GYRUS UNIT-ACTIVITY LTP LESIONS MICE Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory Article 10.1073/pnas.0708644104 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.46, pp.18297 - 18302 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104 46 18297 18302 scie scopus 000251077000072 2-s2.0-36749024575 Multidisciplinary Sciences Science & Technology - Other Topics Article LONG-TERM POTENTIATION BEHAVIORAL STRESS SYNAPTIC PLASTICITY DECLARATIVE MEMORY AUDIOGENIC STRESS DENTATE GYRUS UNIT-ACTIVITY LTP LESIONS MICE consolidation corticosterone hippocampus long-term potentiation single unit