Seo, Han Na Choi, Ja Youn Choe, Yun Jeong Kim, Yoonjee Rhim, Hyewhon Lee, So Ha Kim, Jungahn Joo, Dong Jun Lee, Jae Yeol 2024-01-21T00:05:20Z 2024-01-21T00:05:20Z 2021-08-31 2007-11-01 0960-894X https://pubs.kist.re.kr/handle/201004/133990 The intensive SAR study of 3,.4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC50 = 41 +/- 1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date. (c) 2007 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD BIOLOGICAL EVALUATION STABLE ANGINA DERIVATIVES ANTAGONISTS RELEASE DESIGN MUSCLE PAIN Discovery of potent T-type calcium channel blocker Article 10.1016/j.bmcl.2007.08.070 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.21, pp.5740 - 5743 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 21 5740 5743 scie scopus 000250287800001 2-s2.0-34548828834 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article BIOLOGICAL EVALUATION STABLE ANGINA DERIVATIVES ANTAGONISTS RELEASE DESIGN MUSCLE PAIN T-type calcium channel 3,4-dihydroquinazoline kurtoxin blocker