Nam, Sang-Jip Ko, Hyunsil Ju, Moon Kyeong Hwang, Hoosang Chin, Jungwook Ham, Jungyeob Lee, Byoungchan Lee, Jaehwan Won, Dong Hwan Choi, Hyukjae Ko, Jaeyoung Shin, Kyoungjin Oh, Taekyung Kim, Seokho Rho, Jung-Rae Kang, Heonjoong 2024-01-21T00:05:48Z 2024-01-21T00:05:48Z 2021-09-02 2007-11 0163-3864 https://pubs.kist.re.kr/handle/201004/134013 Three new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 mu M, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy. English AMER CHEMICAL SOC NUCLEAR RECEPTOR LIGAND CHOLESTEROL EXPRESSION Scalarane sesterterpenes from a marine sponge of the genus spongia and their FXR antagonistic activity Article 10.1021/np070024k 1 JOURNAL OF NATURAL PRODUCTS, v.70, no.11, pp.1691 - 1695 JOURNAL OF NATURAL PRODUCTS 70 11 1691 1695 scie scopus 000251179000001 2-s2.0-37249092686 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article NUCLEAR RECEPTOR LIGAND CHOLESTEROL EXPRESSION Marine Sponge Spongia sp. Scalarane Sesterterpenes FXR antagonist