Choi, Hye D. Kang, Hee E. Chung, Hye J. Bae, Soo K. Shin, Karen N. Lee, Myung G. 2024-01-21T00:30:16Z 2024-01-21T00:30:16Z 2021-08-31 2007-11 0142-2782 https://pubs.kist.re.kr/handle/201004/134022 It has been reported that the expressions of hepatic microsomal cytochrome P450 (CYP) 1A1/2,2B1/2 and 3A1/2 were not changed in rats with water deprivation for 72h (rat model of dehydration) compared with the controls. It has been also reported that 1,3-dimethyluric acid (1,3-DMU) was formed from theophylline via CYP1A1/2 in rats. Hence, it could be expected that the formation of 1,3-DMU could be comparable between the two groups of rats. As expected, after both intravenous and oral administration of theophylline at a dose of 5 mg/kg to the rat model of dehydration, the AUC of 1,3-DMU was comparable to the controls. After both intravenous and oral administration of theophylline to the rat model of dehydration, the Cl-r of both theophylline and 1,3DMU was significantly slower than the controls. This could be due to significantly smaller urinary excretions of both theophylline and 1,3-DMU since the AUC of both theophylline and 1,3-DMU were comparable between the two groups of rats. The smaller urinary excretion of both theophylline and 1,3-DMU could be due to urine flow rate-dependent timed-interval renal clearance of both theophylline and 1,3-DMU in rats. Copyright (c) 2007 John Wiley & Sons, Ltd. English JOHN WILEY & SONS LTD URINE FLOW RENAL CLEARANCE EQUILIBRIUM DIALYSIS PROTEIN-BINDING PLASMA CYTOCHROME-P450 EXPRESSION FUROSEMIDE DEPENDENCE KINETICS Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats Article 10.1002/bdd.573 1 BIOPHARMACEUTICS & DRUG DISPOSITION, v.28, no.8, pp.445 - 454 BIOPHARMACEUTICS & DRUG DISPOSITION 28 8 445 454 scie scopus 000251955200006 Pharmacology & Pharmacy Pharmacology & Pharmacy Article URINE FLOW RENAL CLEARANCE EQUILIBRIUM DIALYSIS PROTEIN-BINDING PLASMA CYTOCHROME-P450 EXPRESSION FUROSEMIDE DEPENDENCE KINETICS theophylline 1,3-DMU pharmacokinetics water deprivation for 72 h CYP1A1/2,2B1/2 and 3A1/2 rats