Park, Hyeong Beom Jo, Nam Hyun Hong, Joon Hee Chel, Jung Hoon Cho, Jung-Hyuck Yoo, Kyung Ho Oh, Chang-Hyun 2024-01-21T00:31:24Z 2024-01-21T00:31:24Z 2021-09-02 2007-10 0365-6233 https://pubs.kist.re.kr/handle/201004/134075 The synthesis of a new series of 1 beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem. and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity. English WILEY-V C H VERLAG GMBH BETA-LACTAM ANTIBIOTICS ANTIBACTERIAL ACTIVITY CARBAPENEM ANTIBIOTICS THIENAMYCIN DERIVATIVES Synthesis and in-vitro activity of novel 1 beta-methylcarbapenems having spiro[2,4]heptane moieties Article 10.1002/ardp.200700060 1 ARCHIV DER PHARMAZIE, v.340, no.10, pp.530 - 537 ARCHIV DER PHARMAZIE 340 10 530 537 scie scopus 000250488600004 2-s2.0-35548999250 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article BETA-LACTAM ANTIBIOTICS ANTIBACTERIAL ACTIVITY CARBAPENEM ANTIBIOTICS THIENAMYCIN DERIVATIVES antibacterial activity 1 beta-methylcarbapenems spiro[2,4]heptane substituent effects