Chung, Hwan Won Lee, Kyu Whan Oh, Jung Soo Cho, Seung Joo 2024-01-21T00:31:51Z 2024-01-21T00:31:51Z 2021-09-02 2007-09-30 1738-642X https://pubs.kist.re.kr/handle/201004/134096 Stimulation of epidermal growth factor receptor (EGFR) is essential in signaling pathway of tumor cells. Thus, EGFR has intensely studied as an anticancer target. We developed hologram quantitative structure activity relationship (HQSAR) models for data set which consists of tricyclic azepine derivatives showing inhibitory activities for EGFR. The optimal HQSAR model was generated with fragment size of 6 to 7 while differentiating fragments having different atom and connectivity. The model showed cross-validated q(2) value of 0.61 and non-cross-validated r(2) value of 0.93. When the model was validated with an external set excluding one outlier, it gave predictive r(2) value of 0.43. The contribution maps generated from this model were used to interpret the atomic contribution of each atom to the overall inhibition activity. This can be used to find more efficient EGFR inhibitors. English KOREAN SOC TOXICOGENOMICS & TOXICOPROTEOMICS HQSAR study of tricyclic azepine derivatives as an EGFR (Epidermal growth factor receptor) inhibitors Article 1 MOLECULAR & CELLULAR TOXICOLOGY, v.3, no.3, pp.159 - 164 MOLECULAR & CELLULAR TOXICOLOGY 3 3 159 164 scie kci other 000249869600002 Biochemistry & Molecular Biology Toxicology Biochemistry & Molecular Biology Toxicology Article HQSAR EGFR kinase inhibitor tricyclic azepine