Kim, Youn-Jung Ryu, Jae-Chun 2024-01-21T00:31:52Z 2024-01-21T00:31:52Z 2021-09-02 2007-09-30 1738-642X https://pubs.kist.re.kr/handle/201004/134097 Butylated hydroxytoluene (BHT) is widely used antioxidant food additives. It has been extensively studied for potential toxicities. BHT appears adverse effects in liver and thyroid. In this study, we evaluated the genetic toxicity of BHT with more advanced methods, in vitro mouse lymphoma. assay tk(+/-) gene assay (MLA) and in vivo mouse supravital micronucleus (MN) assay. BHT did not appear the significantly results in the absence and presence of metabolic activation system with MLA. Also, in vivo testing of BHT yielded negative results with supravital MN assay. These results suggest that BHT itself was not generally considered genotoxic. English KOREAN SOC TOXICOGENOMICS & TOXICOPROTEOMICS HYDROXYANISOLE MUTAGENICITY GENOTOXICITY CARCINOGENS LIVER ANTIOXIDANTS WORKSHOP SYSTEM SPERM RATS Evaluation of the genetic toxicity of synthetic chemical (XVIII)-in vitro mouse lymphoma assay and in vivo supravital micronucleus assay with butylated hydroxytoluene (BHT) Article 1 MOLECULAR & CELLULAR TOXICOLOGY, v.3, no.3, pp.172 - 176 MOLECULAR & CELLULAR TOXICOLOGY 3 3 172 176 scie kci other 000249869600004 Biochemistry & Molecular Biology Toxicology Biochemistry & Molecular Biology Toxicology Article HYDROXYANISOLE MUTAGENICITY GENOTOXICITY CARCINOGENS LIVER ANTIOXIDANTS WORKSHOP SYSTEM SPERM RATS butylated hydroxytoluene in vitro Mouse Lymphoma Assay in vivo supravital micronucleus assay Genotoxicity