Lee, Sang Hee
Kim, Inseong
Chung, Bong Chul
2024-01-21T00:32:57Z
2024-01-21T00:32:57Z
2021-09-02
2007-09
0009-9120
https://pubs.kist.re.kr/handle/201004/134148
Objective: Oxidative stress may play an important role in the pathogenesis of Alzheimer's disease (AD). Design and methods: To investigate the possible role of oxidative DNA damage in the pathogenesis of AD, we measured the metabolite concentrations of oxidized nucleosides (pseudouridine, 1-methyladenosine, 5-methylcytidine, 5-methyl-2 '-deoxycytidine, 3-methyluridine, N-2, N-2-dimethylguanosine, 8-hydroxy-2 '-deoxyguano sine, 5-deoxyadenosine and 2-deoxyguanosine) in urine between AD (n=36) and control subjects (n=34) using liquid chromatography-mass spectrometry (LC-MS) without urine preparation. Results: In AD, the 3-methyluridine, 1-methyladenosine, 8-hydroxy-2 '-deoxyguanosine (p < 0.05, respectively), 2-deoxyguanosine (p < 0.01) and pseudouridine, N-2, N-2-dimethylguanosine (p < 0.001, respectively) were significantly increased when compared with the control subjects. Conclusion: The results indicate that oxidized urinary nucleosides may be useful as biomarkers for AD in early stages. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
English
PERGAMON-ELSEVIER SCIENCE LTD
OXIDATIVE DNA-DAMAGE
LIPID-PEROXIDATION
PROTEIN OXIDATION
BRAIN
STRESS
Increased urinary level of oxidized nucleosides in patients with mild-to-moderate Alzheimer's disease
Article
10.1016/j.clinbiochem.2006.11.021
1
CLINICAL BIOCHEMISTRY, v.40, no.13-14, pp.936 - 938
CLINICAL BIOCHEMISTRY
40
13-14
936
938
scie
scopus
000249422200003
2-s2.0-34548162663
Medical Laboratory Technology
Medical Laboratory Technology
Article
OXIDATIVE DNA-DAMAGE
LIPID-PEROXIDATION
PROTEIN OXIDATION
BRAIN
STRESS
alzheimer&apos
s disease
urine
oxidized nucleosides
liquid chromatography-mass spectrometry