Kim, Seong Jong Park, Hyeong Beom Lee, Jae Seoung Jo, Nam Hyun Yoo, Kyung Ho Baek, Daejin Kang, Byoung-won Cho, Jung-Hyuck Oh, Chang-Hyun 2024-01-21T00:33:19Z 2024-01-21T00:33:19Z 2021-09-02 2007-09 0223-5234 https://pubs.kist.re.kr/handle/201004/134166 The synthesis of a new series of 1 beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1, 1-dioxide moiety showed the most potent antibacterial activity. (c) 2007 Elsevier Masson SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER BETA-LACTAM ANTIBIOTICS CARBAPENEMS DERIVATIVES Novel 1 beta-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity Article 10.1016/j.ejmech.2007.02.001 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.42, no.9, pp.1176 - 1183 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 42 9 1176 1183 scie scopus 000249540900003 2-s2.0-34547759867 Chemistry, Medicinal Pharmacology & Pharmacy Article BETA-LACTAM ANTIBIOTICS CARBAPENEMS DERIVATIVES 1 beta-methylcarbapenems antibacterial activity substituent effects