Park, Jungyul Kim, Il Chaek Baek, Jeongeun Cha, Misun Kim, Jinseok Park, Sukho Lee, Junghoon Kim, Byungkyu 2024-01-21T00:33:35Z 2024-01-21T00:33:35Z 2021-08-31 2007-09 1473-0197 https://pubs.kist.re.kr/handle/201004/134178 This paper presents a hybrid micropump actuated by the up-down motion of a dome shaped cell-polymer membrane composite. The contractile force induced from self-beating cardiomyocytes cultured on the membrane causes shrinkage and relaxation of a microchamber, leading to a flow in a microchannel. Flow direction is controlled by the geometry of diffuser/nozzle in the microchannel. The fabrication process is noninvasive to cells, thus, cardiomyocytes can robustly maintain their activity for a long time. The fluid motion in the microchannel was monitored by tracking 2 mu m polystyrene beads. A net flow rate of 0.226 nl min(-1) was obtained in our microscale device. Our device demonstrates a unique performance of a cell-microdevice hybrid lab-on-a-chip that does not require any external power source, preventing electrical or heat shock to analytes. English ROYAL SOC CHEMISTRY MICROFLUIDIC DEVICES FORCE Micro pumping with cardiomyocyte-polymer hybrid Article 10.1039/b703900j 1 LAB ON A CHIP, v.7, no.10, pp.1367 - 1370 LAB ON A CHIP 7 10 1367 1370 scie scopus 000249740500028 2-s2.0-34748846254 Biochemical Research Methods Chemistry, Multidisciplinary Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Instruments & Instrumentation Article MICROFLUIDIC DEVICES FORCE cardiomyocyte polymer pump