Jung, Sang Hoon Lee, Jung Min Lee, Hee Ju Kim, Chul Young Lee, Eun Ha Um, Byung Hun 2024-01-21T00:35:09Z 2024-01-21T00:35:09Z 2021-09-02 2007-08 0918-6158 https://pubs.kist.re.kr/handle/201004/134252 To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem (R) apparatus. It is concluded, therefore, that luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications. English PHARMACEUTICAL SOC JAPAN OXIDATIVE STRESS STRUCTURAL REQUIREMENTS PROTEIN GLYCATION FLAVONOIDS RAT COMPLICATIONS PREVENTION SORBINIL Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra Article 10.1248/bpb.30.1569 1 BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.30, no.8, pp.1569 - 1572 BIOLOGICAL & PHARMACEUTICAL BULLETIN 30 8 1569 1572 scie scopus 000249363300039 2-s2.0-34548041862 Pharmacology & Pharmacy Pharmacology & Pharmacy Article OXIDATIVE STRESS STRUCTURAL REQUIREMENTS PROTEIN GLYCATION FLAVONOIDS RAT COMPLICATIONS PREVENTION SORBINIL aldose reductase advanced glycation endproduct phyllostachys nigra luteolin 6-C-(6"-O-trans-caffeoylglucoside) antioxidant diabetic complications