Kim, Se Young Kim, Dong Jin Yang, Beom Seok Yoo, Kyung Ho 2024-01-21T00:35:24Z 2024-01-21T00:35:24Z 2021-09-02 2007-07-20 0253-2964 https://pubs.kist.re.kr/handle/201004/134263 Based on the hit compound 4 derived from focused library, a series of furo[2,3-d]pyrimidines were designed, synthesized and evaluated for the inhibitory activity against Akt1 kinase. And their structure-activity relationships were investigated. Of these compounds, 3a having 2-thienyl and methyl groups at R-1 and R-2 showed the most potent activity with an IC50 value of 24 mu M. Introduction of the thienyl groups at C-5 and C-6 positions significantly improved potency compared to furyl and phenyl groups. English KOREAN CHEMICAL SOC DERIVATIVES PYRIDINE AKT/PKB CANCER POTENT Synthesis and biological evaluation of furo[2,3-d]pyrimidines as Akt1 kinase inhibitors Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.28, no.7, pp.1114 - 1118 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 28 7 1114 1118 scie scopus kci ART001185982 000249465400008 2-s2.0-34547457955 Chemistry, Multidisciplinary Chemistry Article DERIVATIVES PYRIDINE AKT/PKB CANCER POTENT Akt1 kinase inhibitory activity furo[2,3-d]pyrimidines