Choi, S. Na, H. S. Kim, J. Lee, J. Lee, S. Kim, D. Park, J. Chen, C.-C. Campbell, K. P. Shin, H.-S. 2024-01-21T01:00:30Z 2024-01-21T01:00:30Z 2021-09-02 2007-07 1601-1848 https://pubs.kist.re.kr/handle/201004/134299 Although T-type Ca2+ channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility in mice lacking Ca(V)3.2 subtype of T-type Ca2+ channels (Ca(V)3.2(-/-)) with wild-type littermates in various behavioral models of pain to explore the roles of Ca(V)3.2 in the processing of noxious stimuli in vivo. In acute mechanical, thermal and chemical pain tests, Ca(V)3.2(-/-) mice showed decreased pain responses compared to wild-type mice. Ca(V)3.2(-/-) mice also displayed attenuated pain responses to tonic noxious stimuli such as intraperitoneal injections of irritant agents and intradermal injections of formalin. In spinal nerve ligation-induced neuropathic pain, however, behavioral responses of Ca(V)3.2(-/-) mice were not different from those of wild-type mice. The present study reveals that the Ca(V)3.2 subtype of T-type Ca2+ channels are important in the peripheral processing of noxious signals, regardless of modality, duration or affected tissue type. English BLACKWELL PUBLISHING ROOT GANGLION NEURONS CALCIUM-CHANNEL CA2+ CHANNELS NEUROPATHIC PAIN SENSORY NEURONS AFFERENT NEURONS REDOX MODULATION FORMALIN TEST GENE FAMILY EXPRESSION Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels Article 10.1111/j.1601-183X.2006.00268.x 1 GENES BRAIN AND BEHAVIOR, v.6, no.5, pp.425 - 431 GENES BRAIN AND BEHAVIOR 6 5 425 431 scie scopus 000247667000003 2-s2.0-33947540792 Behavioral Sciences Neurosciences Behavioral Sciences Neurosciences & Neurology Article ROOT GANGLION NEURONS CALCIUM-CHANNEL CA2+ CHANNELS NEUROPATHIC PAIN SENSORY NEURONS AFFERENT NEURONS REDOX MODULATION FORMALIN TEST GENE FAMILY EXPRESSION chemical pain mechanical pain neuropathic pain spinal nerve ligation ( SNL) thermal pain tonic inflammatory pain