Yoon, Byung Hoon Jung, Ji Wook Lee, Jong-Ju Cho, Young-Wuk Jang, Choon-Gon Jin, Changbae Oh, Tae Hwan Ryu, Jong Hoon 2024-01-21T01:00:49Z 2024-01-21T01:00:49Z 2021-09-02 2007-06-27 0024-3205 https://pubs.kist.re.kr/handle/201004/134313 Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. With the exception of its antioxidant activities, the pharmacological properties of sinapic acid have been rarely reported. The purpose of this study was to characterize the putative anxiolytic-like properties of sinapic acid using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). Sinapic acid (4 mg/kg, p.o.) significantly increased the percentages of time spent in the open arms of the EPM test (P<0.05). In the hole-board test, sinapic acid also significantly increased the number of head-dips at 4 mg/kg (P<0.05). In addition, the anxiolytic-like properties of sinapic acid examined in the EPM test were blocked by flumazenil or bicuculline, which are GABAA antagonists. Moreover, sinapic acid markedly potentiated GABA current in single cortical neurons in a dose-dependant manner, and reactive I-GABA increased to 1.8 times at 1 mu M of sinapic acid. These results suggested that sinapic acid is a prominent anxiolytic agent, and that its anxiolytic-like effects are mediated via GABAA receptors and potentiating Cl- currents. (C) 2007 Elsevier Inc. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD MU-OPIOID AGONIST PROTEIN-KINASE-C PHENOLIC-ACIDS FERULIC ACID ANTIOXIDANT PEROXYNITRITE ACTIVATION EXTRACTS GROWTH L. Anxiolytic-like effects of sinapic acid in mice Article 10.1016/j.lfs.2007.05.007 1 LIFE SCIENCES, v.81, no.3, pp.234 - 240 LIFE SCIENCES 81 3 234 240 scie scopus 000248156800009 2-s2.0-34347214429 Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine Pharmacology & Pharmacy Article MU-OPIOID AGONIST PROTEIN-KINASE-C PHENOLIC-ACIDS FERULIC ACID ANTIOXIDANT PEROXYNITRITE ACTIVATION EXTRACTS GROWTH L. sinapic acid anxiolytic-like effect elevated plus-maze test hole-board test GABA(A) receptor chloride current