Jeon, D. Kim, C. Yang, Y-M. Rhim, H. Yim, E. Oh, U. Shin, H-S. 2024-01-21T01:02:07Z 2024-01-21T01:02:07Z 2021-09-02 2007-06 1601-1848 https://pubs.kist.re.kr/handle/201004/134374 Voltage-dependent N-type Ca2+ channels, along with the P/Q-type, have a crucial role in controlling the release of neurotransmitters or neuromodulators at presynaptic terminals. However, their role in hippocampus-dependent learning and memory has never been examined. Here, we investigated hippocampus-dependent learning and memory and synaptic plasticity at hippocampal CA3-CA1 synapses in mice deficient for the alpha(1B) subunit of N-type Ca2+ channels. The mutant mice exhibited impaired learning and memory in the Morris water maze and the social transmission of food preference tasks. In particular, long-term memory was impaired in the mutant mice. Interestingly, among activity-dependent long-lasting synaptic changes, theta burst- or 200-Hz-stimulation-induced long-term potentiation (LTP) was decreased in the mutant, compared with the wild-type mice. This type of LTP is known to require brain-derived neurotrophic factor (BDNF). It was found that both BDNF-induced potentiation of field excitatory postsynaptic potentials and facilitation of the frequency of miniature excitatory postsynaptic currents (mEPSCs) were reduced in the mutant. Taken together, these results demonstrate that N-type Ca2+ channels are required for hippocampus-dependent learning and memory, and certain forms of LTP. English WILEY HIPPOCAMPAL EXCITATORY SYNAPSES DEPENDENT CALCIUM-CHANNELS NEUROTROPHIC FACTOR NEUROTRANSMITTER RELEASE SYNAPTIC-TRANSMISSION BDNF MODULATION NEURONS PLASTICITY ENHANCEMENT Impaired long-term memory and long-term potentiation in N-type Ca2+ channel-deficient mice Article 10.1111/j.1601-183X.2006.00267.x 1 GENES BRAIN AND BEHAVIOR, v.6, no.4, pp.375 - 388 GENES BRAIN AND BEHAVIOR 6 4 375 388 scie scopus 000246684000009 2-s2.0-34249020422 Behavioral Sciences Neurosciences Behavioral Sciences Neurosciences & Neurology Article HIPPOCAMPAL EXCITATORY SYNAPSES DEPENDENT CALCIUM-CHANNELS NEUROTROPHIC FACTOR NEUROTRANSMITTER RELEASE SYNAPTIC-TRANSMISSION BDNF MODULATION NEURONS PLASTICITY ENHANCEMENT BDNF Ca(v)2.2 Ca2+-channel hippocampus learning and memory LTP